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A Critical Guide to UniProtKB

Attwood TK
F1000Research Bioinformatics Education and Training Collection. 7 2018

Abstract

This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the UniProt protein sequence database, with a particular focus on the UniProt Knowledgebase – UniProtKB. The rationale for creating the resource, its contributing databases and the kinds of information they provide are discussed, and issues behind the quality of their annotations are explored.

Specifically, this Guide introduces the principal components of the UniProt Knowledgebase, and the differences between them. On reading this Guide, users will be able to:

  • identify and explain the characteristic features of UniProtKB/Swiss-Prot and /TrEMBL entries;
  • distinguish annotations that are computed, and hence not experimentally validated;
  • search UniProtKB using keywords, full sequences and peptides, and interpret the results;
  • analyse and track the provenance of annotations; and
  • infer which annotations are likely to be accurate and which erroneous.

Title A Critical Guide to UniProtKB
Authors
Publication Type Miscellaneous
Series title F1000Research Bioinformatics Education and Training Collection. 7
Year of Publication 2018
URL https://f1000research.com/documents/7-1434
DOI https://doi.org/10.7490/f1000research.1116053.1

Topics

Introduction to bioinformatics, The UniProt Knowledgebase, introduction to UniProt, protein sequence databases, training material

Keywords

Introduction to bioinformatics, The UniProt Knowledgebase, introduction to UniProt, protein sequence databases, training material